Unsere Veranstaltungen bieten eine Plattform für den Austausch von Ideen und die Vernetzung von Forschern aus verschiedenen Disziplinen, um Innovationen und Anwendungen sowie neueste Entwicklungen und Forschungsergebnisse im Bereich der Nanowissenschaften und Nanotechnologie voranzutreiben.
Vortrag David Clases Seminar PC und TC
Seminar "Physical and Theoretical Chemistry”
Battling the elements: Rethinking Strategies for Characterising Nano- and Microstructures
David Clases, Thomas Lockwood, Matthias Elinkmann, Lhiam Paton, Lukas Schlatt, Marko Simic, Christian Neuper, Christian Hill, Raquel Gonzalez de Vega
Universität Graz
Nano- and microstructures play a fundamental role in basic biology and geology but are often neglected. In the past, one reason for this was a lack of suitable methods to provide complementary perspectives on integrated and discrete structures and to establish models on parameters such as sizes, masses, composition and number concentrations. Inductively coupled plasma – mass spectrometry (ICP-MS) and its associated techniques initiated a paradigm shift for the investigation of micro- and nanostructures. In its single particle (SP) mode, it is capable to count individual particles rapidly whilst estimating critical particles features in a bottom-up fashion. In conjunction with laser ablation (LA), it provides opportunities to inquire the spatial distribution of elements in micro-scaled microstructures.
This presentation will provide a general overview of ICP-MS principles in both SP and LA-ICP-MS and consider relevant instrumental and methodical facets. New approaches for the characterisation of small and heterogenous structures are covered subsequently and a focus is directed to the analysis of low abundant particles in complex matrices. A second focus is set on the hyphenation of ICP-MS and the implementation of new instrumentation, specifically optical traps and single particle Raman spectroscopy, providing new opportunities to characterise single particles from various perspectives and to create new, more comprehensive bottom-up models.
Friday, 22. November 2024, 2.00 pm
!Besprechungsraum, Heinrichstraße 28, 5th floor!
Vortrag Andreas Hauser Seminar PC und TC
Seminar "Physical and Theoretical Chemistry”
New Strategies for Quantum Control of Nuclear Spins in Molecules
Johannes K. Krondorfer, Matthias Diez and Andreas W. Hauser
TU Graz
Two recently proposed strategies for the manipulation of nuclear spins are presented and evaluated on a theoretical level via a combination of quantum simulation and electronic structure theory.1,2,3 Both suggestions attempt to overcome the problem of addressing specific, single nuclear spins, a problem intrinsic to any method involving magnetic fields.
The first method identifies the vibrational excitation of pseudorotational motions in suitable, highly symmetric molecules as a possible way to generate localized magnetic fields. With the help of these local magnetic fields, even spin states of identical atoms within the same molecule might become individually addressable. The second method exploits the nuclear electric quadrupole moment of non-spherical nuclei to access nuclear spin states through time-dependent electric fields.
Both methods have in common, that they aim for a link between individual nuclear spin manipulation and well established technologies such as microelectronics and quantum optics. On the long run, by introducing pulsed lasers in the optical or IR regime as a tool for spin control, the long coherence times of the nuclear spin degrees of freedom might become accessible via known and proven technology standards.
References
Wilhelmer, R.; Diez, M.; Krondorfer, J. K.; Hauser, A. W. Molecular Pseudorotation in Phthalocyanines as a Tool for Magnetic Field Control at the Nanoscale. J. Am. Chem. Soc. 2024, 146 (21), 14620–14632. https://doi.org/10.1021/jacs.4c01915.
Krondorfer, J. K.; Diez, M.; Hauser, A. W. Optical Nuclear Electric Resonance in LiNa: Selective Addressing of Nuclear Spins through Pulsed Lasers. Phys. Scr. 2024, No. 99, 075307. https://doi.org/10.1088/1402-4896/ad52fe.
Krondorfer, J. K.; Hauser, A. W. Nuclear Electric Resonance for Spatially Resolved Spin Control via Pulsed Optical Excitation in the UV-Visible Spectrum. Phys. Rev. A 2023, 108, 053110. https://doi.org/10.1103/physreva.108.053110.
Friday, 15. November 2024, 2.00 pm
Lecture hall HS 10.01, Heinrichstraße 28, ground floor
Monthly Meeting June 2024
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The NANO GRAZ group convened at BRAVE Analytics, a startup located on the Medical University Graz campus, to explore innovative nanoparticle characterization technologies. The focal point of the meeting was the demonstration of OF2i® (Opto Fluidic Force Induction) [1], a technology developed by BRAVE Analytics that offers real-time, online particle size distribution (PSD) analysis in liquid samples. This method excels at managing highly polydisperse samples and is ideal for monitoring nanoparticle-based product manufacturing processes in real time [2].
In addition to OF2i®, BRAVE Analytics is advancing a RAMAN module [3] designed to extract composition-related information from samples. This development promises to enhance the analytical capabilities of the OF2i® technology further.
Separately, Raphael Hauer, a PhD student under Prof. Dr. Ulrich Hohenester, is working on a Large Particle Count (LPC) module. This module specifically targets the large particle tail of typical PSDs, focusing on particles in the low to medium μm range, providing a critical enhancement to the current particle characterization toolkit.
The session included a comprehensive introduction to the company’s history, detailed explanations of the technologies mentioned, and was concluded with a guided tour through the laboratories. During the tour, Karin Griessmair led a hands-on demonstration, showcasing the practical application of the OF2i® technology.
[1] M. Šimić, et al., Phys. Rev. Appl., 18, 024056 (2022)
[2] M. Šimić, et al., Anal. And Bioanal. Chem., 415, 5181-5191
[3] C. Neuper, et al., ChemRxiv. 2023; doi: 10.26434/chemrxiv-2023-hwgll
Monthly Meeting April 2024
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On April 25, 2024, Laura Wiltschko from the research group led by Prof. Eva Roblegg organized the monthly meeting of the Doctoral Academy NanoGraz. The meeting took place in the library of the Institute of Pharmaceutical Technology and Biopharmacy. Three concise presentations were delivered by PhD candidates, offering insights into ongoing research topics.
After introducing the group members, Laura Wiltschko provided a comprehensive overview of one major sampling method for interstitial fluid, which is utilized in her thesis, namely open flow microperfusion. Following this, Christina Glader presented a segment of her research focusing on real-time quality assurance in continuous nanoparticle manufacturing. Subsequently, Bianca Brandl gave an overview of novel biodegradable subcutaneous implants manufactured via high-resolution 3D printing. Afterwards, a brief laboratory tour was held through the laboratories of pharmaceutical technology. Bianca Brandl showed an ongoing release study of her subcutaneous implants using Sotax and Laura Wiltschko presented a dermal open flow microperfusion setup, where tissue concentrations of a topical formulation were determined in ex vivo human skin.
We hope that sharing our research insights will enrich our interdisciplinary discussions and lead to new future collaborations.
Monthly Meeting March 2024
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The meeting concentrated on the practical aspects of numerical modeling for systems with axial symmetry using COMSOL Multiphysics. A single particle was employed as a model to investigate methods for calculating optical forces and the scattering cross-section of a plane electromagnetic wave in such systems. Furthermore, the concept of multipole decomposition and the techniques for performing these calculations were discussed. The meeting was organized by Sergei Gladyshev, a member of Professor Thomas Weiss's research group.
Monthly Meeting February 2024
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“Optical tweezers were the focus of this February’s NanoGraz meeting.
After a brief introduction to the fundamentals behind the technology, members of the NanoGraz consortium played around with the optical tweezer setup; manipulating structures from silica microbeads to living bacteria!”
Monthly Meeting January 2024
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We conducted our first monthly meeting of the Doctoral Academy NanoGraz on the 25th of January at the Institute of Chemistry (Analytical Chemistry) at the KFU Graz, where our newest member Prof. David Clases gave an introduction into his group’s research, which is centered around particles with dimensions at the micro- and nanoscale (NanoMicroLab). Nanoparticles measure between 1 – 100 nm diameter in at least one dimension of space and often exhibit unique physical and chemical properties, which are not observed for their bulk analogues. These properties depend on size, composition and number concentrations and analytical techniques to determine these parameters are in high demand. However, also larger particles and structures can be found ubiquitously in the environment and in biological systems and we require new perspectives to study and understand them.
In a short presentation, Prof. Clases and his group provided an overview on the facets of inductively coupled plasma-mass spectrometry (ICP-MS) to study and to describe relevant characteristics of individual nanoparticles (Single Particle ICP-MS) as well as to map elemental distribution in microstructures (LA-ICP-MS) quantitatively. In a lab-tour, two of the most modern element mass spectrometers and a laser ablation system were prepared and demonstrated to recover, map, and quantify TiO2 nanoparticles in biological tissues.